How does HBOT influence infection control in chronic wounds?

• A. It delays neutrophil function
• B. It reduces oxygen delivery to tissues
• C. It impairs wound healing
• D. It enhances oxygen delivery and neutrophil function, aiding host defense and wound healing

Answer: (D)

Infection control in chronic wounds hinges on delivering enough oxygen to the tissue so immune cells can effectively kill bacteria and healing can proceed. Hyperbaric oxygen therapy raises tissue oxygen tension by delivering high concentrations of oxygen under pressure, increasing the amount of available oxygen dissolved in plasma and diffusing into hypoxic wound tissue.

With more oxygen available, neutrophils can perform their oxidative burst more effectively, boosting their ability to kill bacteria. This enhances host defense directly at the wound site. Oxygen also supports key healing processes—fibroblast activity, collagen synthesis, and angiogenesis—so the wound can repair itself more efficiently, reducing the susceptibility to ongoing infection.

Thus, HBOT both improves oxygen delivery and enhances neutrophil function, aiding host defense and wound healing. Statements claiming delayed neutrophil function, reduced oxygen delivery, or impaired healing contradict the way HBOT works and would not support better infection control.